body[data-mode="replication-regulator"] {
  --control-blue: #346fa3;
  --control-blue-soft: #e8f1f8;
  --rerep: #c5424b;
  --rerep-dark: #96313c;
  --rerep-soft: #fce8e9;
  --outcome-orange: #8f3f08;
}

.regulation-intro {
  min-height: 150px;
}

.regulation-panel {
  margin-bottom: 1.2rem;
  overflow: hidden;
  border: 1px solid rgba(174, 191, 189, 0.8);
  border-radius: 20px;
  background: rgba(255, 255, 255, 0.97);
  box-shadow: 0 15px 38px rgba(19, 45, 57, 0.08);
}

.control-panel-heading {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 1.5rem;
  padding: 1rem 1.25rem 0.9rem;
  border-bottom: 1px solid var(--line);
}

.control-panel-heading .eyebrow {
  margin-bottom: 0.18rem;
}

.control-panel-heading h2 {
  margin: 0;
  font-size: 1.25rem;
  letter-spacing: -0.035em;
}

.control-panel-actions {
  display: flex;
  align-items: center;
  gap: 0.7rem;
}

.detail-switch {
  display: inline-flex;
  align-items: center;
  gap: 0.52rem;
  cursor: pointer;
  color: var(--ink-soft);
  font-size: 0.74rem;
}

.detail-switch > input {
  position: absolute;
  opacity: 0;
  pointer-events: none;
}

.detail-switch > span {
  position: relative;
  width: 36px;
  height: 21px;
  flex: 0 0 36px;
  border: 1px solid var(--line-dark);
  border-radius: 999px;
  background: #eef2f1;
  transition: background 150ms ease, border-color 150ms ease;
}

.detail-switch > span i {
  position: absolute;
  top: 3px;
  left: 3px;
  width: 13px;
  height: 13px;
  border-radius: 50%;
  background: #fff;
  box-shadow: 0 1px 4px rgba(20, 45, 57, 0.28);
  transition: transform 150ms ease;
}

.detail-switch input:checked + span {
  border-color: var(--purple-dark);
  background: var(--purple-dark);
}

.detail-switch input:checked + span i {
  transform: translateX(15px);
}

.detail-switch input:focus-visible + span {
  outline: 2px solid var(--purple);
  outline-offset: 3px;
}

#reset-controls {
  min-height: 34px;
  padding: 0.35rem 0.72rem;
  border: 1px solid var(--line-dark);
  border-radius: 9px;
  color: var(--ink-soft);
  background: #fff;
  cursor: pointer;
  font-size: 0.68rem;
  font-weight: 820;
}

#reset-controls:hover {
  border-color: var(--teal);
  color: var(--teal-dark);
  background: var(--teal-soft);
}

#reset-controls:focus-visible {
  outline: 2px solid var(--teal);
  outline-offset: 2px;
}

.macro-controls {
  display: grid;
  grid-template-columns: repeat(4, minmax(0, 1fr));
}

.macro-controls[hidden] {
  display: none;
}

.regulation-control,
.molecular-range-control {
  min-width: 0;
  display: grid;
  gap: 0.55rem;
  padding: 1rem 1.15rem 0.9rem;
}

.regulation-control + .regulation-control {
  border-left: 1px solid var(--line);
}

.regulation-control > span,
.molecular-range-control > span {
  display: flex;
  align-items: baseline;
  justify-content: space-between;
  gap: 0.7rem;
}

.regulation-control b,
.molecular-range-control b {
  min-width: 0;
  color: var(--ink);
  font-size: 0.74rem;
}

.regulation-control output,
.molecular-range-control output {
  flex: 0 0 auto;
  color: var(--purple-dark);
  font-size: 0.7rem;
  font-variant-numeric: tabular-nums;
  font-weight: 860;
}

.regulation-control input,
.molecular-range-control input {
  width: 100%;
  margin: 0;
  accent-color: var(--purple-dark);
  cursor: ew-resize;
}

.regulation-control input:focus-visible,
.molecular-range-control input:focus-visible {
  outline: 2px solid var(--purple);
  outline-offset: 3px;
}

.regulation-control > small {
  min-height: 2.25em;
  display: grid;
  grid-template-columns: auto 1fr auto;
  align-items: center;
  gap: 0.42rem;
  color: var(--muted);
  font-size: 0.57rem;
  font-weight: 740;
  text-transform: uppercase;
}

.regulation-control > small i {
  height: 1px;
  background: var(--line);
}

.molecular-controls {
  min-width: 0;
  margin: 0;
  padding: 0.9rem;
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 0.75rem;
  border: 0;
  background: linear-gradient(180deg, #fbfafe, #f8faf9);
}

.molecular-controls[hidden] {
  display: none;
}

.molecular-controls > legend {
  position: absolute;
  width: 1px;
  height: 1px;
  overflow: hidden;
  clip: rect(0, 0, 0, 0);
}

.molecular-panel {
  min-width: 0;
  margin: 0;
  padding: 0;
  overflow: hidden;
  border: 1px solid var(--line);
  border-radius: 12px;
  background: rgba(255, 255, 255, 0.82);
}

.molecular-panel > legend {
  width: 100%;
  padding: 0.75rem 0.9rem 0;
  color: var(--ink);
  font-size: 0.76rem;
  font-weight: 850;
}

.kinase-controls {
  display: grid;
  grid-template-columns: minmax(0, 1fr);
}

.molecular-range-control {
  gap: 0.48rem;
  padding: 0.7rem 0.9rem 0.75rem;
}

.molecular-range-control + .molecular-range-control {
  border-left: 1px solid var(--line);
}

.molecular-range-control b {
  font-size: 0.67rem;
}

.molecular-range-control output {
  font-size: 0.64rem;
}

.range-poles {
  min-height: 1.2em;
  display: grid;
  grid-template-columns: auto 1fr auto;
  align-items: center;
  gap: 0.35rem;
  color: var(--muted);
  font-size: 0.52rem;
  font-weight: 740;
  line-height: 1.28;
  text-transform: uppercase;
}

.range-poles i {
  height: 1px;
  background: var(--line);
}

.kinase-panel > p,
.factor-state-panel > p {
  margin: 0;
  color: var(--muted);
  font-size: 0.58rem;
  line-height: 1.35;
}

.kinase-panel > p {
  padding: 0 0.9rem 0.8rem;
}

.factor-state-panel {
  padding-bottom: 0.85rem;
}

.factor-state-panel > p {
  padding: 0.35rem 0.9rem 0.65rem;
}

.replication-inhibitor {
  grid-column: 1 / -1;
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 1rem;
  padding: 0.72rem 0.9rem;
  border: 1px solid var(--line);
  border-radius: 12px;
  background: rgba(255, 255, 255, 0.82);
}

.replication-inhibitor .detail-switch {
  flex: 0 0 auto;
  color: var(--ink);
}

.replication-inhibitor p {
  margin: 0;
  color: var(--muted);
  font-size: 0.64rem;
  line-height: 1.4;
  text-align: right;
}

.molecular-state-options {
  margin: 0 0.9rem;
  padding: 3px;
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 3px;
  border: 1px solid var(--line-dark);
  border-radius: 9px;
  background: var(--paper-warm);
}

.molecular-state-options label {
  min-width: 0;
  cursor: pointer;
}

.molecular-state-options input {
  position: absolute;
  opacity: 0;
  pointer-events: none;
}

.molecular-state-options span {
  min-height: 2rem;
  padding: 0.35rem 0.25rem;
  display: grid;
  place-items: center;
  border-radius: 6px;
  color: var(--muted);
  font-size: 0.58rem;
  font-weight: 820;
  text-align: center;
}

.molecular-state-options input:checked + span {
  color: #fff;
  background: var(--purple-dark);
}

.molecular-state-options input:focus-visible + span {
  outline: 2px solid var(--purple);
  outline-offset: 2px;
}

.regulation-status-header {
  grid-template-columns: minmax(0, 1.08fr) minmax(520px, 0.92fr);
}

.regulation-readouts {
  gap: 0.5rem;
}

.outcome-row {
  display: flex;
  align-items: center;
  justify-content: flex-end;
  gap: 0.55rem;
  color: var(--muted);
  font-size: 0.61rem;
  font-weight: 790;
  letter-spacing: 0.045em;
  text-transform: uppercase;
}

#outcome-badge {
  min-width: 158px;
  padding: 0.32rem 0.62rem;
  border: 1px solid var(--line-dark);
  border-radius: 999px;
  color: var(--ink-soft);
  background: #f3f6f5;
  font-size: 0.61rem;
  text-align: center;
  white-space: nowrap;
}

#outcome-badge[data-outcome="replicated-once"] {
  border-color: #8bc4ac;
  color: var(--green);
  background: var(--green-soft);
}

#outcome-badge[data-outcome="underreplicated"],
#outcome-badge[data-outcome="no-replication"],
#outcome-badge[data-outcome="delayed"],
#outcome-badge[data-outcome="relicensed"] {
  border-color: #e2ae76;
  color: var(--outcome-orange);
  background: var(--orange-soft);
}

#outcome-badge[data-outcome="overreplicated"],
#outcome-badge[data-outcome="mixed"] {
  border-color: #e19aa0;
  color: var(--rerep-dark);
  background: var(--rerep-soft);
}

.regulation-metrics {
  grid-template-columns: repeat(4, 1fr);
}

.regulation-simulation .playback-controls {
  top: 6.25%;
  left: 4.9%;
  width: 27.5%;
}

.regulation-legend {
  grid-template-columns: repeat(5, minmax(0, 1fr));
}

.legend-relicense b {
  position: absolute;
  top: 5px;
  width: 17px;
  height: 17px;
  border: 4px double var(--rerep);
  border-radius: 50%;
  background: var(--white);
}

.legend-relicense b:first-child { left: 3px; }
.legend-relicense b:last-child { right: 3px; }

.legend-rerep b {
  position: absolute;
  right: 1px;
  left: 1px;
  height: 4px;
  border-radius: 9px;
  background: linear-gradient(90deg, var(--rerep), var(--orange));
}

.legend-rerep b:first-child { top: 7px; }
.legend-rerep b:last-child { top: 17px; }

.regulation-logic {
  margin-top: 1.2rem;
}

.regulation-logic li {
  opacity: 0.72;
}

.regulation-logic li.is-current {
  border-left-color: var(--purple);
  opacity: 1;
}

.regulation-logic li.is-past {
  opacity: 0.86;
}

.regulation-questions {
  margin: 1.2rem 0 2rem;
  overflow: hidden;
  border: 1px solid var(--line);
  border-radius: 20px;
  background: rgba(255, 255, 255, 0.94);
}

.regulation-question-heading {
  display: flex;
  align-items: end;
  justify-content: space-between;
  gap: 1rem;
  padding: 1rem 1.2rem;
  border-bottom: 1px solid var(--line);
}

.regulation-question-heading .eyebrow,
.regulation-question-heading h2,
.regulation-question-heading > p {
  margin: 0;
}

.regulation-question-heading .eyebrow {
  margin-bottom: 0.18rem;
}

.regulation-question-heading h2 {
  font-size: 1.15rem;
  letter-spacing: -0.03em;
}

.regulation-question-heading > p {
  max-width: 31rem;
  color: var(--muted);
  font-size: 0.7rem;
  line-height: 1.45;
  text-align: right;
}

.regulation-question-grid {
  padding: 0.9rem;
}

body.regulation-terms-locked {
  overflow: hidden;
}

.regulation-terms-dialog {
  width: min(43rem, calc(100vw - 2rem));
  max-height: calc(100vh - 2rem);
  margin: auto;
  padding: 1.45rem;
  overflow: auto;
  border: 1px solid rgba(20, 48, 60, 0.14);
  border-radius: 18px;
  color: var(--ink);
  background: rgba(255, 255, 255, 0.99);
  box-shadow: 0 28px 80px rgba(14, 35, 45, 0.34);
}

.regulation-terms-dialog::backdrop {
  background: rgba(18, 39, 50, 0.54);
  backdrop-filter: blur(7px);
}

.regulation-terms-dialog .eyebrow,
.regulation-terms-dialog h2,
.regulation-terms-dialog > p,
.regulation-terms-data p,
.regulation-terms-action p {
  margin: 0;
}

.regulation-terms-dialog .eyebrow {
  margin-bottom: 0.48rem;
  color: var(--orange);
}

.regulation-terms-dialog h2 {
  margin-bottom: 0.65rem;
  font-size: clamp(1.35rem, 4vw, 1.7rem);
  letter-spacing: -0.035em;
}

.regulation-terms-dialog > p {
  color: var(--muted);
  font-size: 0.8rem;
  line-height: 1.5;
}

.regulation-terms-data {
  display: grid;
  gap: 0.38rem;
  margin: 1rem 0;
  padding: 0.9rem 1rem;
  border: 1px solid rgba(14, 138, 127, 0.28);
  border-radius: 12px;
  background: rgba(14, 138, 127, 0.07);
}

.regulation-terms-data strong {
  color: var(--teal-dark);
  font-size: 0.78rem;
}

.regulation-terms-data p {
  color: var(--ink-soft);
  font-size: 0.72rem;
  line-height: 1.48;
}

.regulation-terms-confirmation {
  display: flex;
  gap: 0.65rem;
  align-items: flex-start;
  margin: 0.95rem 0;
  color: var(--ink);
  cursor: pointer;
  font-size: 0.78rem;
  font-weight: 760;
  line-height: 1.42;
}

.regulation-terms-confirmation input {
  flex: 0 0 auto;
  width: 1.25rem;
  height: 1.25rem;
  margin: 0.04rem 0 0;
  accent-color: var(--purple-dark);
}

.regulation-terms-confirmation input:focus-visible {
  outline: 3px solid rgba(90, 62, 166, 0.28);
  outline-offset: 3px;
}

.regulation-terms-action {
  display: grid;
  justify-items: end;
  gap: 0.32rem;
}

.regulation-terms-action button {
  min-width: 9.5rem;
  min-height: 2.8rem;
  padding: 0.65rem 1.2rem;
  border: 1px solid var(--ink);
  border-radius: 10px;
  color: white;
  background: var(--ink);
  font: inherit;
  font-size: 0.72rem;
  font-weight: 850;
  cursor: pointer;
}

.regulation-terms-action button:hover:not(:disabled) {
  border-color: var(--purple-dark);
  background: var(--purple-dark);
}

.regulation-terms-action button:focus-visible {
  outline: 3px solid rgba(90, 62, 166, 0.28);
  outline-offset: 3px;
}

.regulation-terms-action button:disabled {
  border-color: var(--line-dark);
  color: var(--muted);
  background: rgba(232, 229, 240, 0.82);
  cursor: not-allowed;
}

.regulation-terms-action p,
.regulation-terms-action small {
  color: var(--muted);
  font-size: 0.62rem;
  line-height: 1.4;
  text-align: right;
}

.regulation-terms-action small {
  display: block;
}

.regulation-question {
  grid-template-rows: minmax(6.8rem, auto) auto 6rem 6.5rem auto;
}

.question-answer-heading {
  display: flex;
  align-items: baseline;
  justify-content: space-between;
  gap: 0.75rem;
}

.question-length {
  color: var(--muted);
  font-size: 0.61rem;
  font-weight: 700;
  line-height: 1.3;
  text-align: right;
}

.question-length[data-state="near"] {
  color: var(--orange);
}

.question-length[data-state="over"] {
  color: var(--rerep-dark);
  font-weight: 850;
}

.regulation-question textarea[aria-invalid="true"] {
  border-color: var(--rerep);
  box-shadow: 0 0 0 1px rgba(217, 65, 75, 0.16);
}

.regulation-question button:disabled {
  border-color: var(--line-dark);
  color: var(--muted);
  background: rgba(232, 229, 240, 0.82);
  cursor: not-allowed;
  opacity: 0.72;
}

.regulation-question-number {
  width: 34px;
  min-height: 30px;
  display: grid;
  place-items: center;
  border-radius: 9px;
  color: var(--purple-dark);
  background: var(--purple-soft);
  font-size: 0.61rem;
  font-weight: 900;
  letter-spacing: 0.05em;
}

.regulation-question-privacy {
  margin: 0;
  padding: 0 1.2rem 1rem;
  color: var(--muted);
  font-size: 0.62rem;
  line-height: 1.4;
}

#regulation-svg * {
  vector-effect: non-scaling-stroke;
}

#regulation-svg .daughter-track {
  stroke: url(#regulator-daughter-gradient);
}

.activity-key.kinase,
.activity-curve.activity-kinase,
.activity-value-guide.kinase { stroke: var(--red); }
.activity-key.geminin,
.activity-curve.activity-geminin,
.activity-value-guide.geminin { stroke: var(--purple); }
.activity-key.cdt1,
.activity-curve.activity-cdt1,
.activity-value-guide.cdt1 { stroke: var(--teal); }
.activity-key.orc,
.activity-curve.activity-orc,
.activity-value-guide.orc { stroke: var(--control-blue); }

.activity-key-label.kinase { fill: var(--red-dark); }
.activity-key-label.geminin { fill: var(--purple-dark); }
.activity-key-label.cdt1 { fill: var(--teal-dark); }
.activity-key-label.orc { fill: var(--control-blue); }

.activity-dot.kinase { stroke: var(--red); }
.activity-dot.geminin { stroke: var(--purple); }
.activity-dot.cdt1 { stroke: var(--teal); }
.activity-dot.orc { stroke: var(--control-blue); }

.activity-key.geminin,
.activity-curve.activity-geminin { stroke-dasharray: 2 3; }
.activity-key.cdt1,
.activity-curve.activity-cdt1 { stroke-dasharray: 11 3 2 3; }
.activity-key.orc,
.activity-curve.activity-orc { stroke-dasharray: 5 2; }

.rerep-fill {
  fill: rgba(217, 65, 75, 0.11);
  stroke: none;
}

.kymo-fill.rerep-history {
  fill: rgba(217, 65, 75, 0.16);
}

.rerep-track {
  fill: none;
  stroke: url(#rerep-gradient);
  stroke-linecap: round;
  stroke-width: 4;
}

.mcm-ring.round-2 {
  stroke: var(--rerep);
}

.mcm-core.round-2 {
  fill: var(--rerep-soft);
  stroke: var(--rerep-dark);
}

.mcm-label.round-2 {
  fill: var(--rerep-dark);
}

.cmg-body.round-2 {
  fill: var(--rerep-soft);
  stroke: var(--rerep);
}

.cmg-arrow.round-2 {
  fill: var(--rerep);
}

.fork-trace.round-2 {
  stroke: var(--rerep);
  stroke-width: 3.7;
}

.origin-tick.round-2 {
  fill: var(--rerep-soft);
  stroke: var(--rerep-dark);
}

.origin-tick.passive.round-2 {
  fill: #eef2f2;
  stroke: #70868c;
  stroke-dasharray: 2 2;
}

.mcm-trace.round-2 {
  stroke: var(--rerep);
}

.mcm-load-dot.round-2 {
  stroke: var(--rerep);
}

.fire-dot.round-2 {
  fill: var(--rerep);
}

.termination-dot.round-2 {
  fill: var(--rerep-dark);
  stroke: var(--rerep-soft);
}

.event-pulse.rerep-event {
  fill: none;
  stroke: var(--rerep);
}

.rerep-label {
  fill: var(--rerep-dark);
  font-size: 9px;
  font-weight: 880;
  letter-spacing: 0.55px;
  text-anchor: middle;
}

.cdt1-trigger-line {
  stroke: var(--teal-dark);
  stroke-dasharray: 4 4;
  stroke-width: 1.5;
}

@media (max-width: 1050px) {
  .macro-controls {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }

  .regulation-control:nth-child(3) {
    border-top: 1px solid var(--line);
    border-left: 0;
  }

  .regulation-control:nth-child(4) {
    border-top: 1px solid var(--line);
  }

  .molecular-controls {
    grid-template-columns: repeat(3, minmax(0, 1fr));
  }

  .regulation-status-header {
    grid-template-columns: 1fr;
  }

  .regulation-legend {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }

  .regulation-legend > div:nth-child(3),
  .regulation-legend > div:nth-child(5) {
    border-top: 1px solid var(--line);
    border-left: 0;
  }

  .regulation-legend > div:nth-child(4) {
    border-top: 1px solid var(--line);
  }
}

@media (max-width: 760px) {
  .regulation-terms-dialog {
    width: calc(100vw - 1rem);
    max-height: calc(100vh - 1rem);
    padding: 1.05rem;
    border-radius: 14px;
  }

  .regulation-terms-action {
    justify-items: stretch;
  }

  .regulation-terms-action button {
    width: 100%;
  }

  .regulation-terms-action p,
  .regulation-terms-action small {
    text-align: center;
  }

  body[data-mode="replication-regulator"] .simulation-stage {
    padding-inline: 0.25rem;
    overflow-x: auto;
  }

  body[data-mode="replication-regulator"] .simulation-canvas {
    width: 820px;
    max-width: none;
  }

  body[data-mode="replication-regulator"] .simulation-note {
    display: none;
  }
}

@media (max-width: 700px) {
  .control-panel-heading,
  .control-panel-actions {
    align-items: stretch;
  }

  .control-panel-heading {
    flex-direction: column;
  }

  .control-panel-actions {
    justify-content: space-between;
  }

  .molecular-controls {
    grid-template-columns: 1fr;
  }

  .regulation-question-heading {
    flex-direction: column;
    align-items: start;
    gap: 0.5rem;
  }

  .regulation-question-heading > p {
    text-align: left;
  }

  .regulation-metrics {
    grid-template-columns: repeat(2, 1fr);
  }

  .regulation-metrics div:nth-child(3) {
    border-top: 1px solid var(--line);
    border-left: 0;
  }

  .regulation-metrics div:nth-child(4) {
    border-top: 1px solid var(--line);
  }
}

@media (max-width: 520px) {
  .macro-controls,
  .regulation-legend {
    grid-template-columns: 1fr;
  }

  .regulation-control + .regulation-control,
  .regulation-control:nth-child(3),
  .regulation-control:nth-child(4),
  .regulation-legend > div + div {
    border-top: 1px solid var(--line);
    border-left: 0;
  }

  .replication-inhibitor {
    align-items: flex-start;
    flex-direction: column;
  }

  .replication-inhibitor p {
    text-align: left;
  }
}